ashwagandha and coumadin interaction ashwagandha and coumadin interaction

Singh P, Salman KA, Shameem M, Warsi MS. Withania somnifera (L.) Dunal as add-on therapy for COPD patients: a randomized, placebo-controlled, double-blind study. View abstract. Safe For Diabetics? The clinical effects of the herbs on warfarin were categorized as potentiation or inhibition. Press question mark to learn the rest of the keyboard shortcuts, https://www.webmd.com/vitamins/ai/ingredientmono-953/ashwagandha. View abstract. Drug interactions with herbs can be especially risky, too. It is estimated that about one-third of adults in the United States use herbal supplements.1 These supplements are widely used, especially by patients with chronic conditions. There are over 200 possible drug interactions with valerian, so a drug interaction screen is important when using this herb. If you are being treated for depression, speak to your doctor before you use yohimbine or any herbal supplement. Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. The https:// ensures that you are connecting to the Because it can be affected by a large number of herbs, supplements and foods, it's important to consult your physician before taking any supplement with warfarin. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. Some herbs also interact with warfarin by reducing vitamin K synthesis by gut flora or by affecting enzymes involved in the vitamin K cycle; thus, pharmacodynamics play a major role in herbal and warfarin interaction mechanisms. It isn't known if ashwagandha will help people with cancer. Herbal supplements and heart medicines may not mix View abstract. Chauhan S, Srivastava MK, Pathak AK. These include drugs like thyroid desiccated, levothyroxine, or liotrix. Drugs.com. Accessibility Xarelto has multiple elimination pathways. View abstract. Sedatives: Since ashwagandha can both energize and induce restorative sleep, it might negate or amplify the effect of other sedative drugs, especially the benzodiazepines. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. Ashwagandha, also known as 'Indian Ginseng' is an evergreen shrub indigenous to India, the Middle East, and some parts of Africa. Do not stop using any medications without first talking to your doctor. Cardiovasc Ther. The use of ginkgo extract dates back centuries in traditional Chinese medicine. Fundukian, L. ed. 2013;45(4):417-8. Despite the lack of sufficient data to prove the safety and efficacy of these supplements, their use has increased greatly in elderly patients. Accessed Aug 1, 2022 at https://www.drugs.com/fda/kratom-mitragyna-speciosa-powder-products-gaia-ethnobotanical-recall-due-potential-salmonella-14176.html. Prog.Neuropsychopharmacol.Biol.Psychiatry 7-1-2008;32(5):1093-1105. The interactions between warfarin and medicinal herbs described in the literature have been summarized in this paper relying on Medline database (via PubMed) using the key words: warfarin, herbal supplements and interactions. Bjrnsson HK, Bjrnsson ES, Avula B, et al. Minor inhibition was defined by INRs that did not require dosage changes. In general, Ashwagandha is thought to be safe when used in moderate amounts. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Drug interactions with ginger are not well documented; however, it is known to inhibit thromboxane synthetase, which can prolong bleeding time and may rarely cause interactions with anticoagulants like warfarin, aspirin, or other blood thinners. Review on mechanisms and interactions in concomitant use of herbs and warfarin therapy. J Ethnopharmacol. The case reports with severe adverse effects such as spontaneous postoperative bleeding, formation of hematomas, hematemesis, melena, thrombosis, subarachnoid hemorrhage and/or subdural hematomas after concomitant use of warfarin and the medicinal herbs: Panax ginseng, Hypericum perforatum, Salvia milthiorizza, Gingko biloba, Serenoa repens, Angelica sinensis, Vaccinium species, Allium sativum, Zingiber officinale, Tanacetum parthenium, Lucium barbarum, Matricaria chamomilla, Boswellia serrata and Camellia sinensis have been estimated. Patients in the study may take other drugs besides Ashwagandha and Coumadin. Warfarinherbal interactions can be classified based on pharmacokinetics and pharmacodynamics. View abstract. Dasgupta A, Tso G, Wells A. The administration of these herbs and iron-containing supplements should be separated by several hours. TABLE 1: HERBS THAT MAY POTENTIATE THE EFFECT OF WARFARIN, TABLE 2: HERBS THAT MAY INHIBIT THE EFFECT OF WARFARIN. 9-1-2010;10(3):238-246. MedFacts Natural Products. J Evid Based Complementary Altern Med. Info on the most common, potentially dangerous, interactions between drugs & supplements, including Lisinopril interactions and others. These events are due to a lack of patient education and information about drug interactions involving alternative medicines. Disclaimer. There are 626 drugs known to interact with Remeron (mirtazapine), along with 13 disease interactions, and 2 alcohol/food interactions. Take extra care if you are taking iron supplements. Use with anticoagulant drugs like warfarin may decrease the blood thinning effects of the anticoagulant and increase the risk for a clot. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. For example. Accessed Aug 1, 2022 at https://ods.od.nih.gov/, "All Natural" Alternatives for Erectile Dysfunction: A Risky Proposition. 2021 Nov 25;13(2):100510. MAOIs can also have interactions with certain foods such as aged cheeses and cured meats. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Kumar G, Srivastava A, Sharma SK, Rao TD, Gupta YK. Im on warfarin, so there are a ton of drug interactions. 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Ashwagndhas potential drug interactions have only been evaluated on a limited basis, but experts assume that it may have adverse interactions with the following drugs based on the impact Ashwagandha may have on the body: No, Ashwagandha does not possess any qualities that cause it to be habit forming, and the risk of forming an addiction to Ashwagandha is little to none. Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. But does "all-natural" mean they are always safe? Indian J Thorac Cardiovasc Surg. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. CoenzymeQ10, also known as ubiquinone or CoQ10, is an antioxidant found naturally in the heart, kidney, liver and pancrease, but aging and smoking can deplete these natural stores. Select a condition to view a list of vitamins. J Obstet Gynaecol Res 2021. 2016 Oct;83:14-21. doi: 10.1016/j.biopha.2016.06.012. eCollection 2022. If you take anti-seizure medications, check with your doctor before using evening primrose oil. Staff. Coumadin-Herbal Interactions - Pharmacy Times While avoidance of medications in pregnancy is the best course of action, this is not Society tends to treat menopause as a disease; something to be avoided at all costs. Mechanism of CoumadinHerbal Interactions. Warfarin interaction with Matricaria chamomilla - PubMed PLoS One 2021;16(9):e0257843. The phase IV clinical study analyzes what interactions people who take Ashwagandha and Coumadin have. Dr. Dube is an advanced practice clinical pharmacist at the Anticoagulation Management Service at Brigham and Women's Hospital. Neurol India 2009;57:166-71. Food Chem.Toxicol. Nevertheless, be sure to talk to your doctor before adding on ashwagandha to blood pressure medicine, such as: Ashwagandha might increase the effects and adverse effects of thyroid hormone drugs. All rights reserved. This includes people who have had a transplant, are on chemo, or have an autoimmune disease. Even the simple, delicious cranberry can have drug interactions. The concern would be blood pressure drops too lowif combining high blood pressure medications and ashwagandha. The use of the eHealthMe site and its content is at your own risk. View abstract. This site needs JavaScript to work properly. 2019 Jan;35(Suppl 1):3-44. doi: 10.1007/s12055-019-00789-z. Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. Does dextromethorphan interact with my other drugs? Does methotrexate interact with my other drugs? View abstract. Concurrent use of Chinese herbal medicine and anticoagulants may reduce major bleeding events. Ashwagandha might help lower blood sugar in people with type 2 diabetes and lower high cholesterol. Warfarinherbal interactions can be classified based on pharmacokinetics and pharmacodynamics.2 Pharmacokinetic interactions involve the processes by which warfarin is absorbed, distributed, metabolized, and excreted.2 Warfarin is metabolized by cytochrome P450 isoenzymes (CYPs), with CYP2C9 being responsible for the majority of the metabolism of the S-enantiomer of warfarin, which is more potent than the R-enantiomer.2 Herbal supplements that have an effect on CYP3A4 or CYP2C19 are also expected to affect the plasma concentration of warfarin.2 These supplements alter warfarin plasma concentration through the inhibition or induction of warfarin protein binding. 1965;9(1):9-15. J Neurol Sci 2000;176:124-7. Ashwagandha may lower blood sugar (i.e. If you take an oral blood thinner, check with your doctor before consuming unusual amounts of cranberry or cranberry juice. 8600 Rockville Pike ConsumerLab.com name and flask logo are both registered trademarks of ConsumerLab.com, LLC. *All products contain less than 0.3% 9THC. Last updated on Oct 10, 2022. Tumori 8-31-1994;80(4):306-308. There are many conditions garlic has been promoted for: to reduce cholesterol and triglycerides, to prevent cancer, to lower blood sugar levels, and to reduce menstrual pain, among other uses. It's important at least 14 days should elapse between discontinuation of MAOI therapy, an infrequently used treatment for depression, and initiation of treatment with yohimbine. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. other herbs with a sedating effect, such as chamomile, lemon balm, and catnip. fractured ending scene; harold bornstein obituary cause of death; can you play volleyball with a torn acl; gambar teguh sugianto. 2023 Vida Optima. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. You can check other yohimbine interactions here. ashwagandha and coumadin interaction - masrurratib.com Syst Rev. Symptoms of an allergic reaction to Ashwagandha may include: Swelling of the lips, mouth, and airways Difficulty breathing Skin rashes or hives Runny nose Watery eyes Nausea and vomiting Stomach cramping Bloating Loose stools Interactions With Other Supplements or Medications All rights reserved. An official website of the United States government. Check with your doctor or pharmacist for a drug interaction review with St. John's Wort if you take prescription, OTC, vitamin or other herbal or dietary medications. Kava, native to the South Pacific, is a member of the pepper family. I am wondering if it is okay to take with my prescriptions. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. Tell your doctor or pharmacist about all the medications you take, including: Be sure a drug interaction screen is conducted by a healthcare provider each time you start or stop a medication. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Devi, P. U., Sharada, A. C., and Solomon, F. E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. Arch Intern Med 1998:158;2200-11. Elite Continuing Education CE. papain and bromelain), Ginkgo (Ginkgo Biloba) Supplements Review. Venkataraghavan S, Seshadri C, Sundaresan TP, and et al. Take extra care and check with your doctor if you have: Signs of a very bad reaction. View valerian drug interactions here. Indian J Exp Biol. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. View abstract. In most cases, Ashwagandha has shown to have little to no risk of adverse effects. Biomed Pharmacother. Praveenkumar, V., Kuttan, R., and Kuttan, G. Chemoprotective action of Rasayanas against cyclosphamide toxicity. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Supplements are not regulated in the same manner as prescription drugs, so its important that you ensure that you only purchase Ashwagandha from a high-quality source. Some evidence suggests that Ashwagandha may help you sleep better at night, but daytime drowsiness may be an inconvenience for some people. Ashwagandha is used as a tonic (it is sometimes referred to as the Indian ginseng) to improve physical and mental health and to treat a number of specific conditions. Efficacy of Withania somnifera supplementation on adult's cognition and mood. The FDA can and does seize and remove from the market tainted, contaminated, fraudulent or unsafe dietary supplements when they are aware of problems. Call your doctor immediately if you have fever, joint pain, bleeding, skin rash or itch, appetite loss, fatigue, nausea/vomiting, stomach pain, dark colored urine, light colored stools, and/or yellowing of the skin/eyes; these may be signs of liver toxicity. Apricot Kernel - Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate, Phenethylamine (pea) - Magnesium Hydroxide (otc Drug), Bitter Orange - Potassium Chloride (prescription Drug). Some medications, such as those used after a transplant, decrease the activity of the immune system. More are needed for more definitive results. . If you take drugs or herbs that may have blood thinner effects (for example: warfarin), or take NSAIDs like ibuprofen or naproxen, check with your health care provider before using evening primrose oil. 1965;9(3):127-136. Products containing kava may cause liver problems, and taking them with alcohol can increase the risk. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. There is no drug interaction reported. If symptoms persist, discontinue use and consult a doctor. Over 500 drug interactions exist with St. John's Wort and some can be dangerous. For example, kratom is one example that has been involved in many seizures. J Ethnopharmacol 1999;64:91-3. View abstract. Costache II, Miron A, Hncianu M, Aursulesei V, Costache AD, Aprotosoaie AC. Miller LG. PMC Lab studies suggest feverfew may increase the risk of bleeding, especially in people with blood-clotting disorders or using blood thinners to help prevent clots. View abstract. The phase IV clinical study analyzes what interactions people who take Warfarin sodium and Maca maca have. Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. Medicine (Baltimore). Phytother.Res 2010;24(1):129-135. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. Indian J Exp Biol. Ashwagandha might cause sleepiness and slowed breathing. Its effects on arterial blood pressure in anaesthetized dogs. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. A systematic review and meta-analysis of randomized controlled trials. 2003;19(3):211-222. Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. [Herbal medicines--evidence and drug interactions in clinical practice]. Ashwagandha side effects While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. Personalize this study to your gender and age, Pramipexole Dihydrochloride and Abnormal Behavior, Rapamune and Left Ventricular Hypertrophy, Lantus Solostar and Vitamin E drug interaction, Gastroenteritis Pseudomonas and drugs of ingredients of prednisone. Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. Consult your health care provider before taking if you are pregnant or nursing, or have any other medical conditions. Ginseng has been used in Asian countries for its therapeutic effects for centuries. The phase IV clinical study analyzes what interactions people who take Ashwagandha and Coumadin have. ConsumerLab.com uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. I always check for drug interactions. Go to the ER right away. Next Steps to Take. Ge B, Zhang Z, Zuo Z. View abstract. Thanks, I shall try the ashwagandha first. They do list some herbs in the drug interactions section (e.g., St. John's Wort) but ashwagandha is not listed. 2000 Jan 8;355(9198):134-8. doi: 10.1016/S0140-6736(99)06457-0. Acta Nerv Super 1990;32(1):1-5. Warfarin interactions with medicinal herbs - PubMed Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Liver Int. Is it safe to take Ashwagandha and Beta Blockers at the same - reddit Some lab tests of cancer cells have found that ashwagandha might slow down their growth. MAOIs are typically only used when other antidepressants have proven ineffective because they have a higher risk of drug interactions than standard antidepressants. View abstract. This is especially problematic in the use of medications with narrow therapeutic indices, such as warfarin. Integr Cancer Ther. FOIA Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Singh, R. H., Narsimhamurthy, K., and Singh, G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. View abstract. Indian J Physiol Pharmacol. Samuels N. Herbal remedies and anticoagulant therapy. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. Choudhary, M. I., Nawaz, S. A., ul-Haq, Z., Lodhi, M. A., Ghayur, M. N., Jalil, S., Riaz, N., Yousuf, S., Malik, A., Gilani, A. H., and ur-Rahman, A. Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. View abstract. Dosage of drugs is not considered in the study. medicinal mushroom and nootropic ingredients. L-Theanine vs L-Tyrosine: Comparing Benefits, Side Effects & More, L-Theanine and Caffeine: The Nootropic Stack Your Mornings Need, Best Lions Mane Supplement: Everything to Consider. Ashwagandha - Special Subjects - Merck Manuals Consumer Version Caffeine capsules are easy to come by, and it's trivially easy to buy or package up ashwagandha powder in capsule form. 2008;9(6):369-374. ashwagandha and coumadin interaction - vccsrbija.rs Comments will be approved before showing up. government site. Thankfully, not all people experience this side effect, and taking Ashwagandha at night can help to manage these possible effects. While these products are intended to boost health, and may make claims to that effect, robust clinical studies may be lacking. View abstract. 2022 Aug 23;17(8):e0271965. The FDA does not apply the same effectiveness and safety studies used for prescription drugs to herbals, dietary supplements, and their manufacturers. The Gale Encyclopedia of Alternative Medicine, third edition, 2009. Cranberries are a fruit chock full of vitamin C, and some people drink cranberry juice to help prevent urinary tract infections (UTI). However, the practical benefits and risks for people. Of course, theres more to the story that needs to be considered before adding a new supplement to your daily wellness routine. 2 Warfarin is metabolized by cytochrome P450 isoenzymes (CYPs), with CYP2C9 being responsible for the majority of the metabolism blood glucose). Accessed Aug 1, 2022 at https://www.drugs.com/npp/. Kumar S, Bouic PJ, Rosenkranz B. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. And yes you are correct, I don't have blood pressure issues, but still taking 40mg. **If you feel like you might have a medical emergency, then you should absolutely contact your doctor or go to your local ER/Urgent care. Skinmed. Due to the seriousness of many drug interactions, you should consult with your health care provider before using St. John's Wort. low blood sugar). Upadhaya L and et al. generic drugs) are not considered. View abstract. Available for Android and iOS devices. Taking small doses - up to 250mg - of ashwagandha alongside your caffeine can help balance out the effects of both. View abstract. drugs for diabetes and blood pressure). There aren't any specific antidiabetic drugs ashwagandha is known to interact with. Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S. Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. J Clin Lab Anal 2008;22:295-301. Epub 2016 Jun 17. There are over 260 drug interactions with kava, and some of them are serious. Answer (1 of 8): 12 Proven Health Benefits of Ashwagandha and Ashwagandha: It's Powerful Health and Beauty Benefits You Didn't Know About and Ashwagandha: Health benefits and side effects Ashwagandha itself works as a antidepressant. Ashwagandha side effects are rare and almost always mild. Supplements that may interact with this medication include cannabidiol (CBD), grapefruit, St. John's wort, ginkgo and others. What are the Side Effects of Ashwagandha? 2023 eHealthMe.com. View abstract. J Ethnopharmacol 1991;33:91-5. Ahumada F, Aspee F, Wikman G, and et al. Indian J Exp Biol. Likewise, the effects of ashwagandha in nursing . Discuss the use of this supplement with your doctor to be safe. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Taking ashwagandha along with these medications might decrease the effects of these medications. I take warfarin (Coumadin), an anticoagulant drug. To prevent unnecessary adverse drug interactions, health care professionals need to be proactive in caring for their patients. Often, patients do not inform their providers about the use of herbal products; this can significantly hinder patient care and adverse event reporting. There are 645 drugs known to interact with methotrexate, along with 5 disease interactions, and 3 alcohol/food interactions. We comply with the HONcode standard for trustworthy health information. In some parts of the world, people eat ashwagandha shoots, seeds, and fruit. Ashwagandha can increase the activity of the immune system. Indian J Med Res 2015 Jan;141(1):100-6. 2021;51(4):363-365. Learn about supplement interactions with clopidogrel (Plavix). Bethesda, MD 20894, Web Policies Blog Uncategorized ashwagandha and coumadin interaction Uncategorized ashwagandha and coumadin interaction J.Transl.Med. J Funct Morphol Kinesiol. Today, ginseng use is reported to improve the body's resistance to stress and increase vitality, among other uses. In large amounts or when using a poor-quality formulation, Ashwagandha may cause some mild side effects, including: Although side effects are rare in general, nausea and diarrhea are the most common possible side effects of Ashwagandha. The references on the analyzed literature have been investigated in order to collect the existing data. View abstract. View abstract. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. This interaction may increase the risk of bleeding. It is just a general precaution that ashwagandha may decrease blood sugar. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. Here, well cover all of the potential Ashwagandha side effects and what to do when they arise. Animal studies have found that ashwagandha could boost the effects of radiation therapy. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. Curr Clin Pharmacol. Ashwagandha Side Effects + Drug Interactions - Vida Optima 2021;270:113766. selective serotonin reuptake inhibitors (SSRIs), slow down the absorption of iron from your body, Top 9 Ways to Prevent a Deadly Drug Interaction. Cancer Lett 2000;148:9-17. Drugs.com. The .gov means its official. You may need to have your blood clotting tests checked more frequently and may need a change in your anticoagulant dose. View abstract. Check the CoQ10 - warfarin interaction here. Kulkarni S. Progress in Neuro-Psychopharmacology and Biological Psychiatry, July 2008; vol 32: pp 1093-1105. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study.